Article
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.
Blood - 5 Nov 2009
Robins Harlan S, Campregher Paulo V, Srivastava Santosh K, Wacher Abigail, Turtle Cameron J, Kahsai Orsalem, Riddell Stanley R, Warren Edus H, Carlson Christopher S
Abstract excerpt
The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient diversity to recognize the universe of potential pathogens. In alphabeta T cells, which primarily recognize peptide antigens presented by major histocompatibility complex molecules, most of this receptor diversity is contained within the third complementarity-determining region (CDR3) of...
Topics
- Adult
- Base Sequence
- Complementarity Determining Regions
- DNA
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genes, T-Cell Receptor beta
- Genetic Variation
- Humans
- Leukocyte Common Antigens
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction