Article
Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil.
Journal of neuroimmunology - 1 Sept 2007
Brum Doralina Guimarães, Barreira Amilton Antunes, Louzada-Junior Paulo, Mendes-Junior Celso Teixeira, Donadi Eduardo Antônio
Abstract excerpt
Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed...
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