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Article

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.

Diabetes - 1 Dec 2009

Li Xia, Shu Yu-Hsiang, Xiang Anny H, Trigo Enrique, Kuusisto Johanna, Hartiala Jaana, Swift Amy J, Kawakubo Miwa, Stringham Heather M, Bonnycastle Lori L, Lawrence Jean M, Laakso Markku, Allayee Hooman, Buchanan Thomas A, Watanabe Richard M

Abstract excerpt

OBJECTIVE: Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic beta-cells and may regulate insulin secretion. GCK rs1799884 and G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-insulin relationships is not well characterized. RESEARCH DESIGN AND METHODS: We tested whether these variants are...

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Identifiers

PMID: 19741163
DOI: 10.2337/db09-0228
PMCID: PMC2780888

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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