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Article

Molecular basis of organ-specific selection of viral variants during chronic infection.

Journal of virology - 1 Aug 1991

Ahmed R, Hahn C S, Somasundaram T, Villarete L, Matloubian M, Strauss J H

Abstract excerpt

Viral variants of different phenotypes are present in the central nervous system (CNS) and lymphoid tissues of carrier mice infected at birth with the Armstrong strain of lymphocytic choriomeningitis virus. The CNS isolates are similar to the parental virus and cause acute infections in adult mice, whereas the lymphoid isolates cause chronic infections associated with suppressed T-cell responses. In this study,...

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Identifiers

PMID: 2072451
DOI: 10.1128/JVI.65.8.4242-4247.1991
PMCID: PMC248861

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