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Article

Rabies virus quasispecies: implications for pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 1998

Morimoto K, Hooper D C, Carbaugh H, Fu Z F, Koprowski H, Dietzschold B

Abstract excerpt

Passage of the mouse-adapted rabies virus strain CVS-24 (where CVS is challenge virus standard) in BHK cells results in the rapid selection of a dominant variant designated CVS-B2c that differs genotypically and phenotypically from the dominant variant CVS-N2c present in mouse-brain- or neuroblastoma-cell-passaged CVS-24. The glycoprotein of CVS-B2c has 10 amino acid substitutions compared with that of CVS-N2c....

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PMID: 9501231
DOI: 10.1073/pnas.95.6.3152
PMCID: PMC19710

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