Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.

doi:10.1128/JVI.69.6.3933-3937.1995

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Article

Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.

Journal of virology - 1 Jun 1995

Haller B L, Barkon M L, Li X Y, Hu W M, Wetzel J D, Dermody T S, Virgin H W

Abstract excerpt

Mutants of mammalian reoviruses, enteric double-stranded-RNA-containing viruses that spread systemically after primary replication in intestinal tissue, have been extensively studied as models of viral pathogenesis. While reovirus serotype 3 strain Dearing (T3D) causes acute encephalitis in newbo...

Topics

Animals
Animals, Newborn
Brain
Chronic Disease
Intestines
Mice
Mice, SCID
Mutation
Reoviridae
Reoviridae Infections
Virulence

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