Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.

Journal of virology - 1 Jun 1995

Haller B L, Barkon M L, Li X Y, Hu W M, Wetzel J D, Dermody T S, Virgin H W

Abstract excerpt

Mutants of mammalian reoviruses, enteric double-stranded-RNA-containing viruses that spread systemically after primary replication in intestinal tissue, have been extensively studied as models of viral pathogenesis. While reovirus serotype 3 strain Dearing (T3D) causes acute encephalitis in newborn mice, adult severe combined immunodeficient (SCID) mice develop chronic infection with T3D, with some mice living...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chronic Disease

Share to Intestines

Share to Mice, SCID

Share to Mutation

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 7745749
DOI: 10.1128/JVI.69.6.3933-3937.1995
PMCID: PMC189121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.PMID 7745749Read ↗

Reovirus nonstructural protein σ1s is required for establishment of viremia and systemic disseminationSemantic proximity Read ↗

Phenotypic and genotypic characteristics of novel mouse cell line (NIH/3T3)-adapted human enterovirus 71 strains (EV71:TLLm and EV71:TLLmv).Semantic proximity Read ↗

Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model.Semantic proximity Read ↗

Molecular basis of organ-specific selection of viral variants during chronic infection.Semantic proximity Read ↗

Variants in <i>Lrrk2</i> and <i>Snca</i> deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn miceSemantic proximity Read ↗

Reverse Genetics of Murine Rotavirus: A Comparative Analysis of the Wild-Type and Cell-Culture-Adapted Murine Rotavirus VP4 in Replication and Virulence in Neonatal MiceSemantic proximity Read ↗

Development of a reverse-genetics system for murine norovirus 3: long-term persistence occurs in the caecum and colonSemantic proximity Read ↗

A Mouse-Adapted Enterovirus 71 Strain Causes Neurological Disease in Mice after Oral InfectionSemantic proximity Read ↗

Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission.Semantic proximity Read ↗

Genetic determinants of Sindbis virus neuroinvasivenessSemantic proximity Read ↗

Tissue-mediated selection of viral variants: correlation between glycoprotein mutation and growth in neuronal cells.Semantic proximity Read ↗

Single Mutation in the Flavivirus Envelope Protein Hinge Region Increases Neurovirulence for Mice and Monkeys but Decreases Viscerotropism for Monkeys: Relevance to Development and Safety Testing of Live, Attenuated VaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.