Article
Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence.
Journal of virology - 1 Nov 1994
Evans C F, Borrow P, de la Torre J C, Oldstone M B
Abstract excerpt
Infection of neonatal mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (ARM) results in a lifelong persistent infection. Viral variants (cytotoxic T lymphocyte [CTL] negative, persistence positive [CTL- P+]) can be isolated from the lymphoid tissues of such mice. Adult mice inoculated with these CTL- P+ viruses fail to generate sufficient cytotoxic T lymphocytes to clear the acute infection...
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