Article
Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence.
Journal of virology - 1 Nov 1994
Evans C F, Borrow P, de la Torre J C, Oldstone M B
Abstract excerpt
Infection of neonatal mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (ARM) results in a lifelong persistent infection. Viral variants (cytotoxic T lymphocyte [CTL] negative, persistence positive [CTL- P+]) can be isolated from the lymphoid tissues of such mice. Adult mice in...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Glycoproteins
- Immune Tolerance
- Kinetics
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Molecular Sequence Data
- Mutation
- Neurons
- Polymerase Chain Reaction
- RNA, Viral
- T-Lymphocytes, Cytotoxic