Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence.

Abstract excerpt

Isolates of lymphocytic choriomeningitis virus (LCMV) that elicit a cytotoxic T-lymphocyte response (CTL+) have been compared with isolates that suppress the CTL response (CTL-) in an effort to map this phenotype. A single amino acid change in the glycoprotein of the LCMV Armstrong (ARM) strain is consistently associated with the CTL- trait and the ability of the virus to persist (P+). The CTL+ P- parental strain...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Clone Cells
• Cricetinae
• Glycoproteins
• Lymphocytic Choriomeningitis
• Lymphocytic choriomeningitis virus
• Mice
• Mice, Inbred BALB C