Article
Sequence variability of Borna disease virus: resistance to superinfection may contribute to high genome stability in persistently infected cells.
Journal of virology - 1 Sept 2000
Formella S, Jehle C, Sauder C, Staeheli P, Schwemmle M
Abstract excerpt
The RNA genome of Borna disease virus (BDV) shows extraordinary stability in persistently infected cell cultures. We performed bottleneck experiments in which virus populations from single infected cells were allowed to spread through cultures of uninfected cells and in which RNase protection assays were used to identify virus variants with mutations in a 535-nucleotide fragment of the M-G open reading frames. In...
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