Article

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

2020-08-21

Abstract excerpt

<h4>ABSTRACT</h4> Noroviruses are a leading cause of gastrointestinal infection in humans and mice. Understanding human norovirus (HuNoV) cell tropism has important implications for our understanding of viral pathogenesis. Murine norovirus (MNoV) is extensively used as a surrogate model for HuNoV. We previously identified CD300lf as the receptor for MNoV. Here, we generated a Cd300lf conditional knockout ( CD30...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d32dad8c-9271-5975-92c7-b4896c6b5def
DOI: 10.1101/2020.08.19.258467

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirusDOI 10.1101/2020.08.19.258467Read

CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine NorovirusSemantic proximity Read

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirusSemantic proximity Read

Discovery of a proteinaceous cellular receptor for a norovirusSemantic proximity Read

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirusSemantic proximity Read

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells.Semantic proximity Read

Protruding Domain of Capsid Protein Is Necessary and Sufficient To Determine Murine Norovirus Replication and Pathogenesis <i>In Vivo</i>Semantic proximity Read

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunitySemantic proximity Read

TRIM47 inhibits murine norovirus replication in a strain-dependent manner.Semantic proximity Read

Atomic Structure of the Murine Norovirus Protruding Domain and Soluble CD300lf Receptor ComplexSemantic proximity Read

Environmentally-triggered contraction of the norovirus virion determines diarrheagenic potentialSemantic proximity Read

Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal miceSemantic proximity Read

Development of a reverse-genetics system for murine norovirus 3: long-term persistence occurs in the caecum and colonSemantic proximity Read