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Article

Tissue-mediated selection of viral variants: correlation between glycoprotein mutation and growth in neuronal cells.

Journal of virology - 1 Nov 1994

Villarete L, Somasundaram T, Ahmed R

Abstract excerpt

Viral variants with different biological properties predominate in the central nervous system (CNS) and lymphoid tissues of carrier mice infected at birth with the Armstrong strain of lymphocytic choriomeningitis virus. The CNS isolates have the same phenotype as the parental strain and cause acute infections in adult mice, while the spleen-derived isolates cause chronic infections associated with suppressed...

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Identifiers

PMID: 7933132
DOI: 10.1128/JVI.68.11.7490-7496.1994
PMCID: PMC237191

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