Article

Human-specific tandem repeat in <i>CACNA1C</i> modulates responses to neuronal stimulation

2025-09-16

Abstract excerpt

The recent development of long-read sequencing has made it possible to catalog variable number tandem repeats (VNTRs) in the human genome. However, little is known about their functional consequences. Here, we characterized the effect of TRACT, a VNTR that is unique to humans and that has sequence variants linked to risk for bipolar disorder and schizophrenia. By adding or removing this VNTR in both mouse models a...

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Literature Corpus work: 0a03ebc8-ad65-5159-8666-f3003515d127
DOI: 10.1101/2025.09.15.676436

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