Article

Sex significantly impacts the function of major depression-linked variants <i>in vivo</i>

2021-11-04

Abstract excerpt

Genome-wide association studies have discovered blocks of common variants—likely transcriptional-regulatory—associated with major depressive disorder (MDD), though the functional subset and their biological impacts remain unknown. Likewise, why depression occurs in females more frequently than males is unclear. We therefore tested the hypothesis that risk-associated functional variants interact with sex and produc...

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Literature Corpus work: da95f272-1fc6-55b5-831e-d67853d7cce6
DOI: 10.1101/2021.11.01.466849

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