Article
Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
Biological psychiatry - 15 Feb 2011
Malki Karim, Uher Rudolf, Paya-Cano Jose, Binder Elke, Rietschel Marcella, Zobel Astrid, Mors Ole, Hauser Joanna, Henigsberg Neven, Jerman Borut, Souery Daniel, Placentino Anna, Ng Mandy Y, Cohen-Woods Sarah, Sluyter Frans, Farmer Anne, Aitchison Katherine J, Craig Ian W, Lewis Cathryn M, McGuffin Peter, Schalkwyk Leonard C
Abstract excerpt
BACKGROUND: Antidepressant drugs are used as first-line treatment in depression, but response has been shown to be highly heterogeneous, with drugs often failing to have the desired therapeutic effect. We report on an integrative analysis from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study using gene expression from mice to inform prioritization in a human pharmacogenetic study. METHODS: The...
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