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Article

Decreased Nucleus Accumbens Expression of Psychiatric Disorder Risk Gene Cacna1c Promotes Susceptibility to Social Stress.

The international journal of neuropsychopharmacology - 1 May 2017

Terrillion Chantelle E, Francis T Chase, Puche Adam C, Lobo Mary Kay, Gould Todd D

Abstract excerpt

Background: Polymorphisms in the CACNA1C gene are associated with human mood disorders. The rodent social defeat model of stress/mood-disorder susceptibility results in maladaptive consequences mediated by altered function of mesolimbic circuits. Methods: mRNA levels of Cacna1c in the nucleus accumbens of mice exposed to social defeat were assessed. Cacna1c was selectively deleted in the nucleus accumbens of...

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Identifiers

PMID: 28165117
DOI: 10.1093/ijnp/pyw112
PMCID: PMC5417061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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