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Article

Perforin gene variation influences survival in childhood acute lymphoblastic leukemia.

Leukemia research - 1 Feb 2018

Jaworowska Aleksandra, Pastorczak Agata, Trelinska Joanna, Wypyszczak Kamila, Borowiec Maciej, Fendler Wojciech, Sedek Lukasz, Szczepanski Tomasz, Ploski Rafal, Młynarski Wojciech

Abstract excerpt

Although a growing body of data links mutations in the perforin gene with increased susceptibility to hematologic malignancies, no studies discuss their influence on the clinical course of such diseases. The present study examines the impact of perforin gene variation on the clinical outcome in acute lymphoblastic leukemia (ALL) patients. The study enrolled 312 children aged 1-18 years, treated for ALL. PRF1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29304394
DOI: 10.1016/j.leukres.2017.12.011

Genes

PRF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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