Article
Interleukin-8 Rs4073 Genotypes as Prognostic Predictors for Childhood Acute Lymphocytic Leukemia.
Anticancer research - 1 Dec 2023
Hsu Pei-Chen, Chen Chao-Chun, Yang Ya-Chen, Shih Hou-Yu, Chin Yu-Ting, Pei Jen-Sheng, Chang Wen-Shin, Tsai Chia-Wen, Kuo Chien-Chung, Bau DA-Tian
Abstract excerpt
BACKGROUND/AIM: Interleukin 8 (IL-8) is highly expressed in refractory acute lymphocytic leukemia (ALL) cells. This study aimed to investigate the contribution of IL-8 polymorphisms to the risk of childhood ALL. MATERIALS AND METHODS: The genotypes of IL-8 rs4073, rs2227306, rs2227543, and rs1126647 were determined in 266 childhood ALL cases and 266 controls using the PCR-RFLP method. Additionally, we assessed...
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