Article
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.
International journal of obesity (2005) - 1 Feb 2011
Timpson N J, Nordestgaard B G, Harbord R M, Zacho J, Frayling T M, Tybjærg-Hansen A, Smith G Davey
Abstract excerpt
CONTEXT: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed. OBJECTIVE: Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate...
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