Article
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis.
PloS one - 1 Jan 2017
Eriksson Joel, Haring Robin, Grarup Niels, Vandenput Liesbeth, Wallaschofski Henri, Lorentzen Erik, Hansen Torben, Mellström Dan, Pedersen Oluf, Nauck Matthias, Lorentzon Mattias, Nystrup Husemoen Lise Lotte, Völzke Henry, Karlsson Magnus, Baumeister Sebastian E, Linneberg Allan, Ohlsson Claes
Abstract excerpt
CONTEXT: Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. OBJECTIVES: Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. DESIGN: Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. SETTING: Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP,...
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