Article
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
PLoS medicine - 1 Jan 2013
Vimaleswaran Karani S, Berry Diane J, Lu Chen, Tikkanen Emmi, Pilz Stefan, Hiraki Linda T, Cooper Jason D, Dastani Zari, Li Rui, Houston Denise K, Wood Andrew R, Michaëlsson Karl, Vandenput Liesbeth, Zgaga Lina, Yerges-Armstrong Laura M, McCarthy Mark I, Dupuis Josée, Kaakinen Marika, Kleber Marcus E, Jameson Karen, Arden Nigel, Raitakari Olli, Viikari Jorma, Lohman Kurt K, Ferrucci Luigi, Melhus Håkan, Ingelsson Erik, Byberg Liisa, Lind Lars, Lorentzon Mattias, Salomaa Veikko, Campbell Harry, Dunlop Malcolm, Mitchell Braxton D, Herzig Karl-Heinz, Pouta Anneli, Hartikainen Anna-Liisa, Streeten Elizabeth A, Theodoratou Evropi, Jula Antti, Wareham Nicholas J, Ohlsson Claes, Frayling Timothy M, Kritchevsky Stephen B, Spector Timothy D, Richards J Brent, Lehtimäki Terho, Ouwehand Willem H, Kraft Peter, Cooper Cyrus, März Winfried, Power Chris, Loos Ruth J F, Wang Thomas J, Järvelin Marjo-Riitta, Whittaker John C, Hingorani Aroon D, Hyppönen Elina
Abstract excerpt
BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. METHODS AND FINDINGS: We used information from 21 adult cohorts (up...
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