Article
Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.
American journal of human genetics - 6 Feb 2014
Holmes Michael V, Lange Leslie A, Palmer Tom, Lanktree Matthew B, North Kari E, Almoguera Berta, Buxbaum Sarah, Chandrupatla Hareesh R, Elbers Clara C, Guo Yiran, Hoogeveen Ron C, Li Jin, Li Yun R, Swerdlow Daniel I, Cushman Mary, Price Tom S, Curtis Sean P, Fornage Myriam, Hakonarson Hakon, Patel Sanjay R, Redline Susan, Siscovick David S, Tsai Michael Y, Wilson James G, van der Schouw Yvonne T, FitzGerald Garret A, Hingorani Aroon D, Casas Juan P, de Bakker Paul I W, Rich Stephen S, Schadt Eric E, Asselbergs Folkert W, Reiner Alex P, Keating Brendan J
Abstract excerpt
Elevated body mass index (BMI) associates with cardiometabolic traits on observational analysis, yet the underlying causal relationships remain unclear. We conducted Mendelian randomization analyses by using a genetic score (GS) comprising 14 BMI-associated SNPs from a recent discovery analysis to investigate the causal role of BMI in cardiometabolic traits and events. We used eight population-based cohorts,...
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