Article
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2009
Timpson Nicholas J, Harbord Roger, Davey Smith George, Zacho Jeppe, Tybjaerg-Hansen Anne, Nordestgaard Børge G
Abstract excerpt
Elevated blood pressure increases the risk of experiencing cardiovascular events like myocardial infarction and stroke. Current observational data suggest that body mass index may have a causal role in the etiology of hypertension, but this may be influenced by confounding and reverse causation. Through the use of instrumental variable methods, we aim to estimate the strength of the unconfounded and unbiased...
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