Article
The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach.
PLoS medicine - 1 Jan 2012
Nordestgaard Børge G, Palmer Tom M, Benn Marianne, Zacho Jeppe, Tybjaerg-Hansen Anne, Davey Smith George, Timpson Nicholas J
Abstract excerpt
BACKGROUND: Adiposity, assessed as elevated body mass index (BMI), is associated with increased risk of ischemic heart disease (IHD); however, whether this is causal is unknown. We tested the hypothesis that positive observational associations between BMI and IHD are causal. METHODS AND FINDINGS: In 75,627 individuals taken from two population-based and one case-control study in Copenhagen, we measured BMI,...
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