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Article

Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach.

Pharmacogenomics - 1 Aug 2010

Carotenuto Pietro, Roma Cristin, Rachiglio Anna Maria, Tatangelo Fabiana, Pinto Carmine, Ciardiello Fortunato, Nappi Oscar, Iaffaioli R Vincenzo, Botti Gerardo, Normanno Nicola

Abstract excerpt

AIMS: Patients with metastatic colorectal carcinoma (mCRC) carrying activating mutations of the KRAS gene do not benefit from treatment with anti-EGF receptor monoclonal antibodies. Therefore, KRAS mutation testing of mCRC patients is mandatory in the clinical setting to aid in the choice of appropriate therapy. MATERIALS & METHODS: We developed a cost-effective approach for the determination of KRAS mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20712532
DOI: 10.2217/pgs.10.86

Genes

KRAS
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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