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Article

Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer.

Cancer genetics - 1 Aug 2011

Pinto Pedro, Rocha Patrícia, Veiga Isabel, Guedes Joana, Pinheiro Manuela, Peixoto Ana, Pinto Carla, Fragoso Maria, Sanches Evaristo, Araújo António, Alves Fernando, Coutinho Camila, Lopes Paula, Henrique Rui, Teixeira Manuel R

Abstract excerpt

Cetuximab and panitumumab are two monoclonal antibodies targeting the epidermal growth factor receptor that have been approved for treatment of metastatic colorectal cancer. Recent clinical trials found an association between KRAS mutation status and resistance to anti-epidermal growth factor receptor therapy, leading to the recommendation to perform KRAS mutation analysis before cetuximab or panitumumab...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21962894
DOI: 10.1016/j.cancergen.2011.07.003

Genes

KRAS

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