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Article

Targeted KRAS mutation assessment on patient tumor histologic material in real time diagnostics.

PloS one - 4 Nov 2009

Kotoula Vassiliki, Charalambous Elpida, Biesmans Bart, Malousi Andigoni, Vrettou Eleni, Fountzilas George, Karkavelas George

Abstract excerpt

BACKGROUND: Testing for tumor specific mutations on routine formalin-fixed paraffin-embedded (FFPE) tissues may predict response to treatment in Medical Oncology and has already entered diagnostics, with KRAS mutation assessment as a paradigm. The highly sensitive real time PCR (Q-PCR) methods developed for this purpose are usually standardized under optimal template conditions. In routine diagnostics, however,...

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Identifiers

PMID: 19888477
DOI: 10.1371/journal.pone.0007746
PMCID: PMC2768905

Genes

KRAS
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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