KRAS Mutation Detection by Real-Time and Digital PCR in Tumor Tissue and Plasma and Its Association with Survival in Stage II-IV Colorectal Cancer: A Kazakhstan Cohort Study.

doi:10.3390/genes17080907

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KRAS Mutation Detection by Real-Time and Digital PCR in Tumor Tissue and Plasma and Its Association with Survival in Stage II-IV Colorectal Cancer: A Kazakhstan Cohort Study.

Genes - 31 Jul 2026

Nasrytdinov Timur, Kaidarova Dilyara, Israilova Venera, Khaidarov Saken, Nurgaliyeva Bayan, Izmailova Slu, Rapilbekova Gulmira, Rabandiyarov Marat, Abdygalyk Bibigul, Aidarov Askar, Aidarov Daulet, Aidarova Aray

Abstract excerpt

BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) is molecularly heterogeneous, and the KRAS (Kirsten rat sarcoma viral oncogene homolog) genotype both governs eligibility for anti-EGFR (epidermal growth factor receptor) therapy and carries prognostic weight. Central Asian data are scarce: no Kazakhstani series has described the KRAS variant spectrum, linked it to survival, or reported mutation detection rates...