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Article

Clinical benefit of high-sensitivity KRAS mutation testing in metastatic colorectal cancer treated with anti-EGFR antibody therapy.

Oncology - 1 Jan 2012

Kimura Tetsuo, Okamoto Koichi, Miyamoto Hiroshi, Kimura Masako, Kitamura Shinji, Takenaka Hidetaka, Muguruma Naoki, Okahisa Toshiya, Aoyagi Eriko, Kajimoto Mayumi, Tsuji Yasushi, Kogawa Takahiro, Tsuji Akihito, Takayama Tetsuji

Abstract excerpt

OBJECTIVE: We compared high-sensitivity KRAS mutation testing with direct sequencing for predicting the efficacy of antiepidermal growth factor receptor antibodies in patients with metastatic colorectal cancer (mCRC). METHODS: We analyzed the KRAS status in 61 tumors from cetuximab-treated mCRC patients by both direct sequencing and a high-sensitivity method: 2-step PCR restriction fragmentation length...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22555244
DOI: 10.1159/000336792

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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