Article
The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR.
Biochemical and biophysical research communications - 23 Apr 2010
Kobunai Takashi, Watanabe Toshiaki, Yamamoto Yoko, Eshima Kiyoshi
Abstract excerpt
PURPOSE: Kirsten rat sarcoma (KRAS) gene mutations occur early in the progression of colorectal adenoma to carcinoma. The mutation status of the KRAS gene determines the benefits of molecular targeting drugs in patients with advanced colorectal cancer, although many methods are available to detect such mutations. The purpose of this study was to evaluate the influence of assay sensitivity on the detection...
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