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Article

KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice.

BMC cancer - 1 Dec 2010

Sundström Magnus, Edlund Karolina, Lindell Monica, Glimelius Bengt, Birgisson Helgi, Micke Patrick, Botling Johan

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor inhibitor therapy is now approved for treatment of metastatic colorectal carcinomas (CRC) in patients with tumors lacking KRAS mutations. Several procedures to detect KRAS mutations have been developed. However, the analytical sensitivity and specificity of these assays on routine clinical samples are not yet fully characterised. METHODS: The practical aspects and...

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Identifiers

PMID: 21122130
DOI: 10.1186/1471-2407-10-660
PMCID: PMC3002357

Genes

KRAS
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice.PMID 21122130Read ↗

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