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KRAS and NRAS mutational analysis in plasma ctDNA from patients with metastatic colorectal cancer by real-time PCR and digital PCR.

International journal of colorectal disease - 1 Apr 2022

Pinheiro Manuela, Peixoto Ana, Rocha Patricia, Veiga Isabel, Pinto Carla, Santos Catarina, Pinto Pedro, Guerra Joana, Escudeiro Carla, Barbosa Ana, Silva João, Teixeira Manuel R

Abstract excerpt

PURPOSE: Mutations in the KRAS and NRAS (RAS) genes are negative predictors of response to anti-EGFR therapy in metastatic colorectal cancer (mCRC). The detection of mutations in circulating tumor DNA (ctDNA) has emerged as a less invasive strategy to assess the molecular profile of mCRC patients. We aimed to perform RAS mutational analysis in ctDNA from mCRC patients using BEAMing Digital PCR (OncoBEAM) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35303157
DOI: 10.1007/s00384-022-04126-6

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