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Article

Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer.

Cancer medicine - 1 Feb 2013

Chretien Anne-Sophie, Harlé Alexandre, Meyer-Lefebvre Magali, Rouyer Marie, Husson Marie, Ramacci Carole, Harter Valentin, Genin Pascal, Leroux Agnès, Merlin Jean-Louis

Abstract excerpt

KRAS mutation detection represents a crucial issue in metastatic colorectal cancer (mCRC). The optimization of KRAS mutation detection delay enabling rational prescription of first-line treatment in mCRC including anti-EGFR-targeted therapy requires robust and rapid molecular biology techniques. Routine analysis of mutations in codons 12 and 13 on 674 paraffin-embedded tissue specimens of mCRC has been performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24133623
DOI: 10.1002/cam4.47
PMCID: PMC3797557

Genes

KRAS
EGFR
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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