Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unraveling the clonal hierarchy of somatic genomic aberrations.

Genome biology - 26 Aug 2014

Prandi Davide, Baca Sylvan C, Romanel Alessandro, Barbieri Christopher E, Mosquera Juan-Miguel, Fontugne Jacqueline, Beltran Himisha, Sboner Andrea, Garraway Levi A, Rubin Mark A, Demichelis Francesca

Abstract excerpt

Defining the chronology of molecular alterations may identify milestones in carcinogenesis. To unravel the temporal evolution of aberrations from clinical tumors, we developed CLONET, which upon estimation of tumor admixture and ploidy infers the clonal hierarchy of genomic aberrations. Comparative analysis across 100 sequenced genomes from prostate, melanoma, and lung cancers established diverse evolutionary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Algorithms

Share to Clonal Evolution

Share to Computational Biology

Share to Genome, Human

Share to Melanoma

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25160065
DOI: 10.1186/s13059-014-0439-6
PMCID: PMC4167267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unraveling the clonal hierarchy of somatic genomic aberrations.PMID 25160065Read ↗

cloneMap: a R package to visualise clonal heterogeneitySemantic proximity Read ↗

Reconstructing tumor clonal heterogeneity and evolutionary relationships based on tumor DNA sequencing data.Semantic proximity Read ↗

Computational Approaches for the Investigation of Intra-tumor Heterogeneity and Clonal Evolution from Bulk Sequencing Data in Precision Oncology Applications.Semantic proximity Read ↗

A new branch on the tree: next-generation sequencing in the study of cancer evolution.Semantic proximity Read ↗

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clustersSemantic proximity Read ↗

Translating insights into tumor evolution to clinical practice: promises and challengesSemantic proximity Read ↗

Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumorsSemantic proximity Read ↗

Sc-TUSV-Ext: Single-Cell Clonal Lineage Inference from Single Nucleotide Variants, Copy Number Alterations, and Structural Variants.Semantic proximity Read ↗

The evolutionary history of 2,658 cancers.Semantic proximity Read ↗

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.Semantic proximity Read ↗

Palimpsest: an R package for studying mutational and structural variant signatures along clonal evolution in cancer.Semantic proximity Read ↗

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.