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Article

The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.

The Journal of biological chemistry - 14 Feb 2020

Witham Christopher M, Dassanayake Hasindu G, Paxman Aleshanee L, Stevens Kofi L P, Baklous Lamprini, White Paris F, Black Amy L, Steuart Robert F L, Stirling Colin J, Schulz Benjamin L, Mousley Carl J

Abstract excerpt

The endoplasmic reticulum (ER) is the entry point to the secretory pathway and major site of protein biogenesis. Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the evolutionarily conserved Sec61 complex, a heterotrimeric channel that comprises the Sec61p/Sec61α, Sss1p/Sec61γ, and Sbh1p/Sec61β subunits. In addition to forming a protein-conducting channel, the...

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Identifiers

PMID: 31848225
DOI: 10.1074/jbc.RA119.010378
PMCID: PMC7029116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.PMID 31848225Read ↗

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