Article
Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.
The Biochemical journal - 1 Jun 2011
Falcone Domina, Henderson Matthew P, Nieuwland Hendrik, Coughlan Christine M, Brodsky Jeffrey L, Andrews David W
Abstract excerpt
Sss1p, an essential component of the heterotrimeric Sec61 complex in the ER (endoplasmic reticulum), is a tail-anchored protein whose precise mechanism of action is largely unknown. Tail-anchored proteins are involved in many cellular processes and are characterized by a single transmembrane sequence at or near the C-terminus. The Sec61 complex is the molecular machine through which secretory and membrane...
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