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Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p.

The EMBO journal - 1 Aug 1997

Wilkinson B M, Esnault Y, Craven R A, Skiba F, Fieschi J, K'epès F, Stirling C J

Abstract excerpt

The heterotrimeric Sec61p complex is a key component of the protein translocation apparatus of the endoplasmic reticulum membrane. The complex characterized from yeast includes Sec61p, a 10-transmembrane-domain membrane protein which has a direct interaction with Sss1p, a small C-terminal anchor...

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Mutation
Molecular Sequence Data
Base Sequence
Amino Acid Sequence
Escherichia coli
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Fungal Proteins

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Identifiers

PMID: 9303299
DOI: 10.1093/emboj/16.15.4549
PMCID: PMC1170081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9303299-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p.PMID 9303299Read ↗

Sss1p is required to complete protein translocon activation.Semantic proximity Read ↗

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.Semantic proximity Read ↗

The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.Semantic proximity Read ↗

Distinct domains within yeast Sec61p involved in post-translational translocation and protein dislocation.Semantic proximity Read ↗

Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum.Semantic proximity Read ↗

SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking.Semantic proximity Read ↗

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.Semantic proximity Read ↗

Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1.Semantic proximity Read ↗

Bacterial protein translocation requires only one copy of the SecY complex in vivo.Semantic proximity Read ↗

Nearest neighbor analysis of the SecYEG complex. 1. Identification of a SecY-SecG interface.Semantic proximity Read ↗

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