Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.

doi:10.1016/j.atherosclerosis.2010.07.021

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Article

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.

Atherosclerosis - 1 Nov 2010

Sofat Reecha, Casas Juan P, Kumari Meena, Talmud Philippa J, Ireland Helen, Kivimaki Mika, Marmot Michael, Hughes Alun D, Thom Simon, Ebrahim Shah, Whittaker John C, Smeeth Liam, Lawlor Debbie A, Humphries Steve E, Hingorani Aroon D

Abstract excerpt

OBJECTIVES: To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis. BACKGROUND: Age-related macular degeneration (AMD) and CHD may share partially overlapping pathogenesis. A non-synonymous SNP (rs1061170/Y402H) in CFH encoding complement factor H (fH) is robustly associated with increased AMD risk but associations with CHD risk have been...

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PMID: 20708732
DOI: 10.1016/j.atherosclerosis.2010.07.021

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