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Article

Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population.

BMC medical genetics - 18 Sept 2007

Meng Weihua, Hughes Anne, Patterson Chris C, Belton Christine, Kamaruddin Muhammad S, Horan Paul G, Kee Frank, McKeown Pascal P

Abstract excerpt

BACKGROUND: The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based a...

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Identifiers

PMID: 17877809
DOI: 10.1186/1471-2350-8-62
PMCID: PMC2048938

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17877809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population.PMID 17877809Read ↗

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.Semantic proximity Read ↗

Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction.Semantic proximity Read ↗

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.Semantic proximity Read ↗

Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population.Semantic proximity Read ↗

Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation.Semantic proximity Read ↗

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.Semantic proximity Read ↗

A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.Semantic proximity Read ↗

No association of complement factor H gene polymorphism and age-related macular degeneration in the Japanese population.Semantic proximity Read ↗

The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors.Semantic proximity Read ↗

Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease.Semantic proximity Read ↗

Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Semantic proximity Read ↗

Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study.Semantic proximity Read ↗

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