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Article

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.

Nature genetics - 1 Sept 2006

Li Mingyao, Atmaca-Sonmez Pelin, Othman Mohammad, Branham Kari E H, Khanna Ritu, Wade Michael S, Li Yun, Liang Liming, Zareparsi Sepideh, Swaroop Anand, Abecasis Gonçalo R

Abstract excerpt

In developed countries, age-related macular degeneration is a common cause of blindness in the elderly. A common polymorphism, encoding the sequence variation Y402H in complement factor H (CFH), has been strongly associated with disease susceptibility. Here, we examined 84 polymorphisms in and around CFH in 726 affected individuals (including 544 unrelated individuals) and 268 unrelated controls. In this sample,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16936733
DOI: 10.1038/ng1871
PMCID: PMC1941700

Genes

CFH

Variants

Provenance

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Related research

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CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.PMID 16936733Read ↗

A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.Semantic proximity Read ↗

Complement factor H variant increases the risk of age-related macular degeneration.Semantic proximity Read ↗

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.Semantic proximity Read ↗

Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.Semantic proximity Read ↗

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.Semantic proximity Read ↗

Complement factor H polymorphism in age-related macular degeneration.Semantic proximity Read ↗

Association of CFH Y402H polymorphism with both forms of advanced age-related macular degeneration in Turkish patients.Semantic proximity Read ↗

Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration.Semantic proximity Read ↗

[Y402H polymorphism in complement factor H and age-related macula degeneration (AMD)].Semantic proximity Read ↗

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.Semantic proximity Read ↗

Association of complement factor H polymorphisms with exudative age-related macular degeneration.Semantic proximity Read ↗

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