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Article

Can genetic associations change with age? CFH and age-related macular degeneration.

Human molecular genetics - 1 Dec 2012

Adams Madeleine K M, Simpson Julie A, Richardson Andrea J, Guymer Robyn H, Williamson Elizabeth, Cantsilieris Stuart, English Dallas R, Aung Khin Zaw, Makeyeva Galina A, Giles Graham G, Hopper John, Robman Liubov D, Baird Paul N

Abstract excerpt

Genetic variation in the gene encoding complement factor H (CFH) on chromosome 1q31 has repeatedly been associated with an increased risk of age-related macular degeneration (AMD); however, previous studies have had inadequate numbers of participants across a sufficiently wide age range to determine whether the association varies by age. We conducted a genetic case-control study using data from 2294 cases and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22936692
DOI: 10.1093/hmg/dds364

Genes

CFH

Variants

rs1061170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Can genetic associations change with age? CFH and age-related macular degeneration.PMID 22936692Read ↗

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