Article
Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).
The American journal of cardiology - 15 Aug 2007
Kardys Isabella, de Maat Moniek P M, Klaver Caroline C W, Despriet Dominiek D G, Uitterlinden André G, Hofman Albert, de Jong Paulus T V M, Witteman Jacqueline C M
Abstract excerpt
Complement factor H (CFH) is an important regulator of the complement cascade. Binding of C-reactive protein (CRP) to CFH augments the ability of CFH to downregulate the effect of complement in atherosclerotic lesions. The CFH Tyr402His polymorphism has been suggested to influence the ability of CFH to bind CRP. We hypothesized that the combined presence of unfavorable CRP and CFH genetic profiles is associated...
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