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Article

Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.

European heart journal - 1 Jun 2007

Pai Jennifer K, Manson JoAnn E, Rexrode Kathryn M, Albert Christine M, Hunter David J, Rimm Eric B

Abstract excerpt

AIMS: Complement factor H (CFH) Y402H polymorphism is located in a region that binds C-reactive protein and may affect inflammatory processes and risk of coronary heart disease (CHD). We assessed the association between Y402H and risk of CHD in nested case-control studies among two large prospective cohorts of US male health professionals and female nurses. METHODS AND RESULTS: Among participants who were...

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Source

Identifiers

PMID: 17483111
DOI: 10.1093/eurheartj/ehm090

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.PMID 17483111Read ↗

Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study.Semantic proximity Read ↗

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.Semantic proximity Read ↗

A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.Semantic proximity Read ↗

Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).Semantic proximity Read ↗

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.Semantic proximity Read ↗

Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study.Semantic proximity Read ↗

Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Semantic proximity Read ↗

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.Semantic proximity Read ↗

Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.Semantic proximity Read ↗

Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease.Semantic proximity Read ↗

Complement factor H gene polymorphism and risk of cardiovascular disease in end-stage renal disease patients.Semantic proximity Read ↗

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