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Article

Complement factor H polymorphism in age-related macular degeneration.

Science (New York, N.Y.) - 15 Apr 2005

Klein Robert J, Zeiss Caroline, Chew Emily Y, Tsai Jen-Yue, Sackler Richard S, Haynes Chad, Henning Alice K, SanGiovanni John Paul, Mane Shrikant M, Mayne Susan T, Bracken Michael B, Ferris Frederick L, Ott Jurg, Barnstable Colin, Hoh Josephine

Abstract excerpt

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15761122
DOI: 10.1126/science.1109557
PMCID: PMC1512523

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15761122-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Complement factor H polymorphism in age-related macular degeneration.PMID 15761122Read ↗

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Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.Semantic proximity Read ↗

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Role of genetic factors and inflammation in age-related macular degeneration.Semantic proximity Read ↗

Complement factor H polymorphism and age-related macular degeneration.Semantic proximity Read ↗

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.Semantic proximity Read ↗

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Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

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The role of molecular genetic factors in age-related macular degeneration.Semantic proximity Read ↗

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.Semantic proximity Read ↗

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