Article
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.
Mechanisms of ageing and development - 1 Sept 2010
Rahn Jennifer J, Lowery Megan P, Della-Coletta Luis, Adair Gerald M, Nairn Rodney S
Abstract excerpt
Werner syndrome (WS) is a rare, segmental progeroid syndrome caused by defects in the WRN gene, which encodes a RecQ helicase. WRN has roles in many aspects of DNA metabolism including DNA repair and recombination. In this study, we exploited two different recombination assays previously used to describe a role for the structure-specific endonuclease ERCC1-XPF in mitotic and targeted homologous recombination. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.