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Article

The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.

Genetics - 1 Jun 2014

Bolterstein Elyse, Rivero Rachel, Marquez Melissa, McVey Mitch

Abstract excerpt

Members of the RecQ family of helicases are known for their roles in DNA repair, replication, and recombination. Mutations in the human RecQ helicases, WRN and BLM, cause Werner and Bloom syndromes, which are diseases characterized by genome instability and an increased risk of cancer. While WRN contains both a helicase and an exonuclease domain, the Drosophila melanogaster homolog, WRNexo, contains only the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24709634
DOI: 10.1534/genetics.114.164228
PMCID: PMC4063921

Genes

WRN
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.PMID 24709634Read ↗

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.Semantic proximity Read ↗

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.Semantic proximity Read ↗

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathwaySemantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.Semantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

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