Article
Allele-sharing statistics using information on family history.
Annals of human genetics - 1 Nov 2010
Callegaro A, Meulenbelt I, Kloppenburg M, Slagboom P E, Houwing-Duistermaat J J
Abstract excerpt
When conducting genetic studies for complex traits, large samples are commonly required to detect new genetic factors. A possible strategy to decrease the sample size is to reduce heterogeneity using available information. In this paper we propose a new class of model-free linkage analysis statistics which takes into account the information given by the ungenotyped affected relatives (positive family history)....
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