Article
A comparison of some allele-sharing based linkage analysis methods for detecting complex trait loci.
Genetic epidemiology - 1 Jan 1999
Liu Y, Mirea L, Pinnaduwage D, Fallah S, Tritchler D
Abstract excerpt
Using randomly selected sib pairs from a subset of the GAW11 simulated data in Problem 2, we compared the results of some linkage analysis methods based on allele sharing. One method was the Haseman-Elston test for a binary disease outcome (unaffected vs. mild or severe). The other methods, which analyzed the trinary ordered outcome unaffected/mild/severe were the Haseman-Elston test, an extended Haseman-Elston...
Topics
- Alleles
- Genetic Linkage
- Genetic Testing
- Humans
- Models, Genetic
- Models, Statistical
- Nuclear Family
- Quantitative Trait, Heritable
- Regression Analysis