Using family history information to distinguish true and false positive model-free linkage results.

doi:10.1002/(SICI)1098-2272(1998)15:2<183::AID-GEPI6>3.0.CO;2-7

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Article

Using family history information to distinguish true and false positive model-free linkage results.

Genetic epidemiology - 1 Jan 1998

Olson J M, Elston R C

Abstract excerpt

Genome scans that test for increased marker identity-by-descent sharing between pairs of affected siblings have become increasingly common. These methods do not specify a priori a genetic model for the disease locus and as such lose the ability to specify the parental source of the disease allele...

Topics

Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Humans
Lod Score
Medical History Taking
Models, Genetic
Reproducibility of Results
Sex Characteristics

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