Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMOylation modulates the function of Aurora-B kinase.

Journal of cell science - 15 Aug 2010

Fernández-Miranda Gonzalo, Pérez de Castro Ignacio, Carmena Mar, Aguirre-Portolés Cristina, Ruchaud Sandrine, Fant Xavier, Montoya Guillermo, Earnshaw William C, Malumbres Marcos

Abstract excerpt

Aurora kinases are central regulators of mitotic-spindle assembly, chromosome segregation and cytokinesis. Aurora B is a member of the chromosomal passenger complex (CPC) with crucial functions in regulation of the attachment of kinetochores to microtubules and in cytokinesis. We report here that Aurora B contains a conserved SUMO modification motif within its kinase domain. Aurora B can bind SUMO peptides in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Chromosome Segregation

Share to Cytokinesis

Share to Spindle Apparatus

Share to SUMO-1 Protein

Share to Sumoylation

Source

Open in PubMed Open full text

Identifiers

PMID: 20663916
DOI: 10.1242/jcs.065565
PMCID: PMC2915883

Genes

INCENP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMOylation modulates the function of Aurora-B kinase.PMID 20663916Read ↗

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian developmentSemantic proximity Read ↗

SUMO targets the APC/C to regulate transition from metaphase to anaphaseSemantic proximity Read ↗

SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.Semantic proximity Read ↗

Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation.Semantic proximity Read ↗

Aurora kinases link chromosome segregation and cell division to cancer susceptibility.Semantic proximity Read ↗

The Aurora B kinase in Trypanosoma brucei undergoes post-translational modifications and is targeted to various subcellular locations through binding to TbCPC1.Semantic proximity Read ↗

Aurora B Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

A small C-terminal sequence of Aurora B is responsible for localization and function.Semantic proximity Read ↗

The Aurora kinases: role in cell transformation and tumorigenesis.Semantic proximity Read ↗

The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.Semantic proximity Read ↗

Aurora B regulates MCAK at the mitotic centromere.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.