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Article

A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.

EMBO reports - 1 Jan 2018

Liang Cai, Chen Qinfu, Yi Qi, Zhang Miao, Yan Haiyan, Zhang Bo, Zhou Linli, Zhang Zhenlei, Qi Feifei, Ye Sheng, Wang Fangwei

Abstract excerpt

Sister-chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin is protected from Wapl until anaphase onset. Strong centromere cohesion requires centromeric localization of the mitotic histone kinase Haspin, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29138236
DOI: 10.15252/embr.201744737
PMCID: PMC5757254

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